Alpine County is the smallest county, by population, in California. There are no incorporated cities in the county. The county seat is Markleeville. Alpine County is located in the Sierra Nevada, between Lake Tahoe and Yosemite National Park. In 2000 there were 483 households, and 295 families residing in the county. The population density was 1/km² (2/mi²). The county has a total area of 743 mi². 739 mi² of it is land and 5 mi² of it (0.61%) is water. For every 100 females there were 110.80 males. The median income for a household in the county was $41,875.